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October 5, 2025Learning Health SystemsOpen Access

Empirical research related to the ethics of pragmatic clinical trials: A scoping review

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Authors

KMKayla R. MehlSMStephanie R. MorainJSJeremy Sugarman

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Overview

Scoping review highlights ethical concerns in pragmatic clinical trials, suggesting the need for enhanced stakeholder engagement and trust-building.

Key Points

  • Addressing gaps in ethical research enhances the understanding of pragmatic clinical trials.
  • Key themes identified include informed consent, risk assessment, and stakeholder engagement.
  • Challenges in trust and transparency impact participant perceptions and trial implementation.
  • Research is predominantly centered in Western contexts with limited generalizability.

Cite This Study

Mehl et al. (2025) studied this question.

synapsesocial.com/papers/68e25378d6d66a53c2474285https://doi.org/10.1002/lrh2.70041
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