Photoredox-catalyzed hydrocarbamoylation shows high regio- and chemoselectivity in allylamines.
Herein, a photoredox‐catalyzed protocol for allylamine hydrocarbamoylation under metal‐free and mild conditions is reported. The proposed method utilizes readily accessible 4‐carboxyamido Hantzsch esters as convenient substrates that deliver carbamoyl radicals upon a visible light‐mediated SET process. Their addition to various allylamines proceeds with good‐to‐excellent efficiency and with high levels of regio‐ and chemoselectivity to provide the corresponding γ‐amino acid amides.
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Zalewski et al. (2025) studied this question.
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