A visible‐light‐promoted, nitrogen‐centered radical‐initiated trifunctionalization of 5‐hexenenitriles via diamidation and 1,4‐cyano migration, using 1 mol% fac‐Ir(ppy)₃ as the photoredox catalyst, is reported. In this protocol, the O‐acylhydroxylamine derivative acts as a bifunctional reagent, and the carbonitrile solvent also participates in the reaction. This transformation proceeds at room temperature without the need for an external oxidant or reductant, yielding a wide range of functionalized β‐amino nitriles, including the derivatives of natural products and pharmaceuticals.
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Ghouse et al. (2024) studied this question.
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