A mild and general method for photoredox-catalyzed trifluoromethylative and pentafluoroethylative heterofunctionalization of alkenes is proposed. In this reaction, the Togni reagent serves as a CF3- or CF2CF3-radical source for the regioselective formation of the C–CF3 and C–CF2CF3 bonds from alkenes, and additional nucleophiles (O, S, N) provide C–O, C–S, and C–N bonds, respectively. These reactions provide a common gateway to access the fluoroalkylative heterofunctionalization of alkenes.
No takes yet. Share an insight, caveat, or question.
Choi et al. (2024) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: