Supplementary Figure S7 from CRISPR Dependency Screens in Primary Hematopoietic Stem Cells Identify KDM3B as a Genotype-specific Vulnerability in IDH2- and TET2-mutant Cells

Michael R. Waarts; Shoron Mowla; Meaghan Boileau; Anthony R. Martinez Benitez; Junya Sango; Maya Bagish; Inés Fernández-Maestre; Yufan Shan; Shira E. Eisman; Young C. Park; Matthew Wereski; Isabelle Csete; Kavi O’Connor; Angélica C. Romero‐Vega; Linde A. Miles; Wenbin Xiao; Xiaodi Wu; Richard P. Koche; Scott A. Armstrong; Alan H. Shih; Eirini P. Papapetrou; Jason M. Butler; Sheng F. Cai; Robert L. Bowman; Ross L. Levine

doi:10.1158/2159-8290.27168792

Key Points

KDM3B dependency emerges as a genotype-specific vulnerability in IDH2- and TET2-mutant cells, showing a functional link to 2-HG accumulation and enzymatic activity.
CRISPR dependency screens in primary hematopoietic stem cells demonstrate selective cellular lethality driven by loss of KDM3B catalytic activity.
Targeting KDM3B enzymatic function may offer a targeted therapeutic strategy for specific myeloid genotypes; preclinical cell model requires clinical validation.

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Implication

CRISPR screens reveal KDM3B dependency in IDH2- and TET2-mutant primary hematopoietic stem cells, highlighting a genotype-specific vulnerability linked to 2-HG and catalytic activity.

Abstract

Role of 2-HG and KDM3B catalytic activity in KDM3B dependency

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Waarts et al. (2024) studied this question.

synapsesocial.com/papers/68e55da7e2b3180350efada0 https://doi.org/10.1158/2159-8290.27168792

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Supplementary Figure S7 from CRISPR Dependency Screens in Primary Hematopoietic Stem Cells Identify KDM3B as a Genotype-specific Vulnerability in IDH2- and TET2-mutant Cells

Key Points

No abstract yet

Implication

Abstract

Discussion

Cite This Study

Supplementary Figure S7 from CRISPR Dependency Screens in Primary Hematopoietic Stem Cells Identify KDM3B as a Genotype-specific Vulnerability in IDH2- and TET2-mutant Cells

Key Points

No abstract yet

Implication

Abstract

Discussion

Cite This Study

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