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October 3, 2024AJP Renal Physiology

Deletion of AT1a receptors selectively in the proximal tubules alters the hypotensive and natriuretic response to ANP via NPRA/cGMP/NO Signaling

Xiao‐Chun Li Chih-Hong Wang Rumana Hassan Akemi Sato Ryosuke Sato Jia L. Zhuo

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In the kidney, vasoactive peptide hormones angiotensin II (Ang II), via AT

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Li et al. (2024) studied this question.

synapsesocial.com/papers/68e55db8e2b3180350efb5dd https://doi.org/10.1152/ajprenal.00160.2024

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Deletion of AT<sub>1a</sub> Receptors Selectively in Renomedullary Interstitial Cells Attenuates Basal, Angiotensin II-, or Vasopressin-induced Vasoactive Factors' mRNA Expression in The Mouse Kidney Medulla2024
2Angiotensin II AT2 receptor decreases AT1 receptor expression and function via nitric oxide/cGMP/Sp1 in renal proximal tubule cells from Wistar–Kyoto ratspreclinical · 2012 · 59 citations
3Angiotensin Type-2 Receptors: Transducers of Natriuresis in the Renal Proximal Tubulereview · 2022 · 14 citations
4Role of angiotensin <scp>AT</scp><sub>2</sub> receptors in natriuresis: Intrarenal mechanisms and therapeutic potentialreview · 2013 · 46 citations
5Angiotensin II AT<sub>2</sub>receptors inhibit proximal tubular Na<sup>+</sup>-K<sup>+</sup>-ATPase activity via a NO/cGMP-dependent pathwaypreclinical · 2005 · 72 citations

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A Key Role of AT<sub>1a</sub> Receptors and Na<sup>+</sup>/H<sup>+</sup> Exchanger 3 in The Proximal Tubules in Angiotensin II-induced and Two-Kidney, One-Clip Goldblatt Hypertension2025
Sustained hypersensitivity to angiotensin II and its mechanism in mice lacking the subtype-2 (AT <sub>2</sub> ) angiotensin receptor1999
Renal segmental microvascular responses to ANG II in AT<sub>1A</sub>receptor null mice2003

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