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October 1, 2024PNAS NexusOpen Access

Reprogramming with Atoh1, Gfi1, and Pou4f3 promotes hair cell regeneration in the adult organ of Corti

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Authors

MMMelissa M. McGovernUniversity of PittsburghSGSumana GhoshJackson Memorial HospitalCDColleen DupuisBaylor College of Medicine

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Cite This Study

McGovern et al. (2024) studied this question.

synapsesocial.com/papers/68e5600ee2b3180350efd529https://doi.org/10.1093/pnasnexus/pgae445
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Damage-Induced Activation of ERK1/2 in Cochlear Supporting Cells Is a Hair Cell Death-Promoting Signal That Depends on Extracellular ATP and Calcium2008 · 118 citations
  2. 2Preparation of the mammalian organ of Corti for scanning electron microscopy*1987 · 81 citations
  3. 3Cellular reprogramming with ATOH1, GFI1, and POU4F3 implicate epigenetic changes and cell-cell signaling as obstacles to hair cell regeneration in mature mammals2022 · 87 citations
  4. 4Spontaneous Hair Cell Regeneration Is Prevented by Increased Notch Signaling in Supporting Cells2018 · 37 citations