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November 30, 2025Annual Review of GeneticsOpen Access

The Field of Hair Cell Regeneration Is Ready for Input from Genomics and Epigenetics

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Authors

DSDonald L. SwiderskiLWLindsey M. Q. WilsonYRYehoash Raphael

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Overview

This research reveals how gene transfer technology may induce transdifferentiation of supporting cells into hair cells, indicating potential therapeutic interventions for hearing loss.

Key Points

  • Transdifferentiation of supporting cells may improve hearing outcomes, but results are inconsistent.
  • Gene transfer technology demonstrated proof of principle for hair cell regeneration, with challenges in quality.
  • Observational analysis reveals insights from transgenesis and developmental biology for cochlear regeneration strategies.
  • Future studies on gene expression and epigenetic regulation could enhance therapeutic approaches to hearing loss.

Cite This Study

Swiderski et al. (2025) studied this question.

synapsesocial.com/papers/692b94261d383f2b2a37832dhttps://doi.org/10.1146/annurev-genet-011725-100840
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Hair cell regeneration, reinnervation, and restoration of hearing thresholds in the avian hearing organ2024 · 18 citations
  2. 2Vestibular Mechanisms1975 · 121 citations
  3. 3Davis--1961 Revisited: Signal Transmission in the Cochlear Hair Cell-Nerve Junction1975 · 13 citations
  4. 4Detection of ultrasonic tones and simulated dolphin echolocation clicks by a teleost fish, the American shad (Alosa sapidissima)1998 · 110 citations
  5. 5Cellular reprogramming with ATOH1, GFI1, and POU4F3 implicate epigenetic changes and cell-cell signaling as obstacles to hair cell regeneration in mature mammals2022 · 87 citations