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October 1, 2024

Supplementary Figure 7 from Intermittent MEK Inhibition with GITR Costimulation Rescues T-cell Function for Increased Efficacy with CTLA-4 Blockade in Solid Tumor Models

Lauren Dong Hyejin Choi Sadna Budhu Isabell Schulze Svena Verma Levi Mangarin Valeria Estrada Nevarro Nezar Mehanna Jonathan F. Khan Divya Venkatesh Daniel Thach Neal Rosen Jedd D. Wolchok Taha Merghoub

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Abstract

Supplementary Figure 7. Intermittent CKI27 treatment and GITR co-stimulation relieves expression of co-stimulatory markers. Representative dot plot data for FACS analysis of co-stimulatory markers expressed by CD8+ T cells.

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Cite This Study

Dong et al. (2024) studied this question.

synapsesocial.com/papers/68e56226e2b3180350efee00 https://doi.org/10.1158/2326-6066.27142840

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary Figure 8 from Intermittent MEK Inhibition with GITR Costimulation Rescues T-cell Function for Increased Efficacy with CTLA-4 Blockade in Solid Tumor Models2024
2Supplementary Figure 6 from Intermittent MEK Inhibition with GITR Costimulation Rescues T-cell Function for Increased Efficacy with CTLA-4 Blockade in Solid Tumor Models2024
3Supplementary Figure 9 from Intermittent MEK Inhibition with GITR Costimulation Rescues T-cell Function for Increased Efficacy with CTLA-4 Blockade in Solid Tumor Models2024
4Supplementary Figure 2 from Intermittent MEK Inhibition with GITR Costimulation Rescues T-cell Function for Increased Efficacy with CTLA-4 Blockade in Solid Tumor Models2024
5Supplementary Figure f1 from Intermittent MEK Inhibition with GITR Costimulation Rescues T-cell Function for Increased Efficacy with CTLA-4 Blockade in Solid Tumor Models2024