⌘+K

Pulse Explore Communities Researchers Journals

Home Communities Explore

October 1, 2024

Supplementary Figure 6 from Intermittent MEK Inhibition with GITR Costimulation Rescues T-cell Function for Increased Efficacy with CTLA-4 Blockade in Solid Tumor Models

Lauren Dong Hyejin Choi Sadna Budhu Isabell Schulze Svena Verma Levi Mangarin Valeria Estrada Nevarro Nezar Mehanna Jonathan F. Khan Divya Venkatesh Daniel Thach Neal Rosen Jedd D. Wolchok Taha Merghoub

View Full Paper

Ask AI

Bookmark

Share

Abstract

Supplementary Figure 6. Intermittent CKI27 treatment and GITR co-stimulation relieves expression of co-inhibitory markers. (A) Gating strategy for all T cell activation assays. (B) Representative dot plot data for FACS analysis of co-inhibitory markers expressed by CD8+ T cells.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Dong et al. (2024) studied this question.

synapsesocial.com/papers/68e56226e2b3180350efee02 https://doi.org/10.1158/2326-6066.27142843

View Full Paper

Ask AI

Bookmark

Share

Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary Figure 7 from Intermittent MEK Inhibition with GITR Costimulation Rescues T-cell Function for Increased Efficacy with CTLA-4 Blockade in Solid Tumor Models2024
2Supplementary Figure 8 from Intermittent MEK Inhibition with GITR Costimulation Rescues T-cell Function for Increased Efficacy with CTLA-4 Blockade in Solid Tumor Models2024
3Supplementary Figure 9 from Intermittent MEK Inhibition with GITR Costimulation Rescues T-cell Function for Increased Efficacy with CTLA-4 Blockade in Solid Tumor Models2024
4Supplementary Figure 2 from Intermittent MEK Inhibition with GITR Costimulation Rescues T-cell Function for Increased Efficacy with CTLA-4 Blockade in Solid Tumor Models2024
5Supplementary Figure f1 from Intermittent MEK Inhibition with GITR Costimulation Rescues T-cell Function for Increased Efficacy with CTLA-4 Blockade in Solid Tumor Models2024