A highly selective and sensitive method for detecting methotrexate (MTX) in serum samples using a molecularly imprinted electrochemical sensor have been developed. The preparation of the magnetic molecularly imprinted polymers (MIPs) employed MTX as the template, which was synthesized via sol-gel technology. These polymers were then integrated with carbon paste to create the MMIPs/CPE (MMPE) sensor. Under optimized conditions, the MMPE sensor exhibited outstanding selectivity and sensitivity for MTX detection, with two linear ranges of 0.01–0.5 and 0.5–20.0 μM, and a detection limit of just 1.63 nM. Furthermore, the sensor’s practical application in serum sample analysis demonstrated its efficacy, with recovery rates between 81.0% and 125.0%. This innovation holds promise for clinical diagnosis and therapeutic applications, facilitating accurate and specific MTX detection in serum samples.
No takes yet. Share an insight, caveat, or question.
Sun et al. (2024) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: