Alzheimer’s disease-linked risk alleles elevate microglial cGAS-associated senescence and neurodegeneration in a tauopathy model

Gillian Carling; Li Fan; Nessa R. Foxe; Kendra Norman; Man Ying Wong; Daphne Zhu; Carlo Corona; Agnese Razzoli; Fangmin Yu; Allan Yarahmady; Pearly Ye; Hao Chen; Yige Huang; Sadaf Amin; Rebecca Sereda; Chloe Lopez-Lee; Emmanouil Zacharioudakis; Xiaoying Chen; Jielin Xu; Feixiong Cheng; Evripidis Gavathiotis; Ana María Cuervo; David M. Holtzman; Sue‐Ann Mok; Subhash C. Sinha; Simone Sidoli; Rajiv R. Ratan; Wenjie Luo; Shiaoching Gong; Li Gan

doi:10.1016/j.neuron.2024.09.006

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Abstract

The strongest risk factors for late-onset sporadic Alzheimer's disease (AD) include the ε4 allele of apolipoprotein E (APOE), the R47H variant of triggering receptor expressed on myeloid cells 2 (TREM2), and female sex. Here, we combine APOE4 and TREM2

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Carling et al. (2024) studied this question.

synapsesocial.com/papers/68e56386e2b3180350f00106 https://doi.org/10.1016/j.neuron.2024.09.006

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Alzheimer’s disease-linked risk alleles elevate microglial cGAS-associated senescence and neurodegeneration in a tauopathy model

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Alzheimer’s disease-linked risk alleles elevate microglial cGAS-associated senescence and neurodegeneration in a tauopathy model

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