What question did this study set out to answer?

To determine whether the APOE ε4 allele and flanking polymorphic markers on chromosome 19q13.2 confer risk for early- and late-onset sporadic Alzheimer's disease.

January 1, 1994Human Molecular Genetics

Apolipoprotein E, ɛ4 allele as a major risk factor for sporadic early and late-onset forms of Alzheimer's disease: analysis of the 19q13.2 chromosomal region

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Authors

MCMarie‐Christine Chartier‐HarlinInserm MPMatthew ParfittInserm SLSylvle LegrainHôpital Paul-Brousse

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Implication

Case-control analysis finds APOE e4 increases risk for early- and late-onset Alzheimer's disease, indicating chromosome 19q13.2 genetic involvement.

Key Points

To determine whether the APOE ε4 allele and flanking polymorphic markers on chromosome 19q13.2 confer risk for early- and late-onset sporadic Alzheimer's disease.
Analyzed allelic distributions of four polymorphic markers flanking the APOE gene (D19S178, D19S47, APOCI, APOCII) in late-onset cases (n = 36) vs controls (n = 38) and early-onset cases (n = 34) vs controls (n = 36).
Evaluated early-onset cases using age-at-onset thresholds of <60 and <65 years.
Estimated disease risk using a logistic regression model adjusted for population cohorts.
Carrying at least one APOE ε4 allele significantly increased disease risk across cohorts (adjusted OR = 4.10, 95% CI [1.84; 9.16]), whereas carrying at least one ε2 allele was protective (adjusted OR = 0.11, 95% CI [0.02; 0.50]).
Significant disease associations were identified for APOCII long alleles in late-onset Alzheimer's (OR = 3.56, 95% CI [1.19; 10.70]) and D19S178 short alleles in early-onset Alzheimer's (OR = 4.44, 95% CI [1.27; 15.49]).

Cite This Study

Chartier‐Harlin et al. (1994) studied this question.

synapsesocial.com/papers/6a72a792f44fa9f079e00d56 https://doi.org/10.1093/hmg/3.4.569

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Implication

Case-control analysis finds APOE e4 increases risk for early- and late-onset Alzheimer's disease, indicating chromosome 19q13.2 genetic involvement.

Apolipoprotein E, ɛ4 allele as a major risk factor for sporadic early and late-onset forms of Alzheimer's disease: analysis of the 19q13.2 chromosomal region

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Implication

Key Points

Cite This Study

Apolipoprotein E, ɛ4 allele as a major risk factor for sporadic early and late-onset forms of Alzheimer's disease: analysis of the 19q13.2 chromosomal region

Discussion

Member takes

Implication

Key Points

Cite This Study

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