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This investigation aims to assess the relationship between APOE genotypes and the risk of Alzheimer's disease in a Syrian population.

APOE ε4 and late-onset Alzheimer's disease in Syria: A case-control study

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Case-control study assesses APOE genotypes and Alzheimer's disease risk in Syrian individuals, indicating significant genetic associations.

This investigation aims to assess the relationship between APOE genotypes and the risk of Alzheimer's disease in a Syrian population.
Conducted a case-control study with 52 AD patients and 38 healthy controls.
Extracted genomic DNA and determined APOE genotype through direct sequencing.
Compared genotypic and allelic frequencies using Fisher's exact test.
The ε3/ε4 genotype was found in 23.1% of AD patients but absent in controls (Corrected OR = 12.37, 95% CI = 0.65–233.7, p < 0.01).
The ε4 allele frequency was significantly higher in AD patients (0.117) compared to controls (0.000) (Corrected OR = 10.76, 95% CI = 0.59–195.7, p < 0.01).
No instances of ε2/2, ε4/4, and ε2/4 genotypes were detected.

Labbad et al. (2026) studied this question.

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Case-control study assesses APOE genotypes and Alzheimer's disease risk in Syrian individuals, indicating significant genetic associations.