Epididymo-Orchitis Caused by Hand, Foot, and Mouth Disease in Adults

Hand, Foot, and Mouth disease (HFMD) is predominantly recognized as a childhood disease and is not generally anticipated to manifest in adults. In addition to inducing symptoms such as fever, herpangina, and distal-extremity rashes, HFMD can also lead to rare complications such as encephalitis and onychomadesis. Epididymo-orchitis; however, is not considered an expected complication of HFMD. In our case, a patient diagnosed with HFMD presented with testicular pain four days later, and epididymo-orchitis was subsequently identified in the patient initially suspected of testicular torsion. Cases of Coxsackie virus-related epididymo-orchitis have been reported in the literature, and these cases can be mistaken for torsion, thereby posing the risk of unnecessary surgical interventions. Testicular pain in a young adult with a history of HFMD should be considered as a potential diagnosis of viral epididymo-orchitis.