This case highlights the potential for atypical and severe presentations of hand, foot, and mouth disease in adults.
Atypical adult HFMD warrants diagnostic consideration; case reports extend the clinical spectrum but leave open systematic characterization.
The following report describes a case of hand, foot, and mouth disease (HFMD) in an adult patient, presenting atypical manifestations due to its clinical exuberance.The patient, a 26-year-old physician, reported the onset of fever and odynophagia followed on the 2 nd day by vesicles and enanthema on the soft palate, associated with erythematous papules in the perioral and nasal dorsum regions, extending to the hands and feet.The lesions progressed in severity and number over the days, exhibiting unusual characteristics.Onychomadesis also manifested in the nails after the 6 th week.The diagnostic investigation included a series of serologies, highlighting reactivity to Coxsackievirus.A biopsy of a papulovesicular lesion revealed the presence of keratinocyte necrosis and inflammatory reaction in the dermis.The discussion encompasses the pathogenesis of HFMD, its atypical manifestations in adults, and the importance of diagnostic elucidation.This case report contributes to understanding the clinical variations of HFMD in adults, emphasizing the need to consider this entity even outside the predominant age group.
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Nascimento et al. (2024) studied this question.