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September 30, 2024Journal of Health and Rehabilitation Research

Comparison of Oral Anticoagulants vs. Warfarin for Stroke Prevention in Atrial Fibrillation: A Meta-Analysis

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Authors

OTOkasha TahirISIbad SaleemRARomeysah Adnan

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Overview

Meta-analysis demonstrates reduced stroke risk and mortality with direct oral anticoagulants in atrial fibrillation, highlighting superior efficacy despite increased gastrointestinal bleeding.

Key Points

  • Direct oral anticoagulants significantly decrease ischemic stroke and systemic embolism compared to warfarin, while also reducing all-cause mortality in atrial fibrillation.
  • With a hazard ratio of 0.78, direct oral anticoagulants reduced ischemic stroke or systemic embolism across published studies evaluating 172,350 atrial fibrillation patients.
  • Meta-analysis of randomized controlled trials and observational cohorts supports direct oral anticoagulants as preferred therapy, despite increased gastrointestinal bleeding.

Cite This Study

Tahir et al. (2024) studied this question.

synapsesocial.com/papers/68e56f7db6db6435875107f9https://doi.org/10.61919/jhrr.v4i3.1606
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Direct Acting Oral Anticoagulant vs. Warfarin in the Prevention of Thromboembolism in Patients With Non-valvular Atrial Fibrillation With Valvular Heart Disease—A Systematic Review and Meta-Analysis2021 · 13 citations
  2. 2Abstract 12514: Direct Oral Anticoagulants versus Warfarin for Preventing Thromboembolic Events in Valvular Heart Diseases Associated Atrial Fibrillation: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials2023 · 1 citations
  3. 3Oral anticoagulants for prevention of stroke in atrial fibrillation: systematic review, network meta-analysis, and cost effectiveness analysis2017 · 560 citations
  4. 4Direct Oral Anticoagulants Versus Warfarin in Patients With Atrial Fibrillation: Patient-Level Network Meta-Analyses of Randomized Clinical Trials With Interaction Testing by Age and Sex2022 · 389 citations
  5. 5Comparison of the Direct Oral Anticoagulants and Warfarin in Patients With Atrial Fibrillation and Valvular Heart Disease: Updated Systematic Review and Meta-Analysis of Randomized Controlled Trials2021 · 7 citations