Figure 3 from SREBP-Dependent Regulation of Lipid Homeostasis Is Required for Progression and Growth of Pancreatic Ductal Adenocarcinoma

SCAP is required for human PDAC tumor growth in mouse orthotopic xenograft models. A, Nude mice were orthotopically injected with 5 × 10⁴ Pa03c cells in the tail of the pancreas (one tumor per mouse). Mice were euthanized on day 30 post-surgery and tumors weighed. The wild-type (WT) group contained five mice, and the SCAP KO group contained six mice. Error bar denotes standard deviation. Statistical significance was determined using the Student t test. B, Photograph images of all harvested tumors from A. C, Representative hematoxylin and eosin–stained sections of formalin-fixed tumor tissue from the mice in A showing a low magnification (2×) image (top row) and a higher magnification (20×) image (bottom row) of the tumors.