Figure 1 from SREBP-Dependent Regulation of Lipid Homeostasis Is Required for Progression and Growth of Pancreatic Ductal Adenocarcinoma

SCAP supports PDAC development and loss of SCAP prolongs survival in the KPC mouse model of pancreas cancer. A, Mice of the indicated genotype were aged until death. The figure shows the cumulative incidence curve of death due to PDAC for each genotype group. For the analysis, we considered death due to other causes (i.e., not due to PDAC) as a competing event. The Gray test was used for pairwise comparisons. B, Incidence of adverse event (death due to PDAC) in KPC cohorts from A either pooled (left figure) or stratified by sex (right figure). C, Incidence of PanINs and invasive PDAC identified histologically in KPC cohorts from A. D, Representative hematoxylin and eosin–stained sections of formalin-fixed pancreas tissue from KPC, KPCSfl/+ and KPCSfl/fl cohorts in A showing a magnification (2–4×) image (top row) and a higher magnification (20×) image (bottom row) of the changes in the pancreas. The C mouse is used as a control. E, Figure shows the survival curves by genotype group. Mice of the indicated genotypes were aged until death at which time histology was performed to determine the presence of PanINs and invasive PDAC. For this analysis, we treated time to invasive PDAC as interval-censored data. The permutation test was used for pairwise comparisons.