Figure 1 from KRAS Promotes GLI2-Dependent Transcription during Pancreatic Carcinogenesis

Gli2 promotes Kras-driven PDAC progression in vivo.A, Representation of animal crosses to generate model KCRG mice using CRG and KC mice. B, Kaplan–Meier curve depicting survival in KC and KCRG animals (log-rank test, P = 0.0058). C, Pie charts representing percentage of nontumor and adenocarcinoma incidence in KC (n = 13) and KCRG (n = 15) mice. D, Representative H&E stain of KC and KCRG mice depicting moderately differentiated and poorly differentiated adenocarcinoma. Scale bar, 100 μm. E, Pie charts representing percentage incidence of chronic pancreatitis, moderately differentiated adenocarcinoma, and poorly differentiated adenocarcinoma in Cre (n = 9), CRG (n = 7), KC (n = 13), and KCRG (n = 15) animals.