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September 25, 2024AntioxidantsOpen Access

Withania somnifera (Ashwagandha) Improves Spatial Memory, Anxiety and Depressive-like Behavior in the 5xFAD Mouse Model of Alzheimer’s Disease

Noah Gladen-Kolarsky Olivia Monestime Melissa Bollen Jaewoo Choi Liping Yang Armando Alcázar Magaña Claudia S. Maier Amala Soumyanath Nora E. Gray

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Abstract

(WS), also known as ashwagandha, is a popular botanical supplement used to treat various conditions including memory loss, anxiety and depression. Previous studies from our group showed an aqueous extract of WS root (WSAq) enhances cognition and alleviates markers for depression in

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Cite This Study

Gladen-Kolarsky et al. (2024) studied this question.

synapsesocial.com/papers/68e5765bb6db6435875160c2 https://doi.org/10.3390/antiox13101164

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Withania somnifera (Ashwagandha) Improves Spatial Memory, Anxiety and Depressive-Like Behavior in the 5xFAD Mouse Model of Alzheimer’s Disease2024 · 8 citations
2Efficacy and Safety of Ashwagandha (<i>Withania somnifera</i> (L.) <i>Dunal</i>) Root Extract in Improving Memory and Cognitive FunctionsRCT · 2017 · 214 citations
3Acute and Repeated Ashwagandha Supplementation Improves Markers of Cognitive Function and Mood2024 · 42 citations
4Attenuation Effect of Withania somnifera Extract on Restraint Stress-Induced Anxiety-like Behavior and Hippocampal Alterations in Mice2025
5Withania somnifera showed neuroprotective effect and increased longevity in Drosophila Alzheimer’s disease model2024