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September 25, 2024Journal of Agricultural and Food Chemistry

Fungicidal Activity of Novel 6-Isothiazol-5-ylpyrimidin-4-amine-Containing Compounds Targeting Complex I Reduced Nicotinamide Adenine Dinucleotide Oxidoreductase

Kun Li You Lv Rongzhang Wu Z. Walter Yu Yulin Liang Zecong Yu Ruobing Liang Liang‐Fu Tang Hongyu Chen Zhijin Fan

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Abstract

To discover novel inhibitors of the complex I reduced nicotinamide adenine dinucleotide (NADH) oxidoreductase as fungicides, a series of 6-isothiazol-5-ylpyrimidin-4-amine-containing compounds were designed using a computer-aided pesticide design method and splicing of substructures from diflumetorim and isotianil. In vitro fungicidal bioassays indicated that compounds

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Li et al. (2024) studied this question.

synapsesocial.com/papers/68e5765bb6db6435875161d1 https://doi.org/10.1021/acs.jafc.4c07259

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Design, Synthesis, and Fungicidal Activity of Pyrimidinamine Derivatives as Novel Complex I InhibitorsOriginal Research · 2026 · 1 citations
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4Novel Isoxazolylpyrimidine Derivatives: Design, Synthesis, Antifungal Activity and In‐Silico Studies2024 · 7 citations
5Synthesis, antifungal activity, and mechanism of action of nicotinohydrazides bearing a biphenyl fragment as potential broad‐spectrum fungicidesOriginal Research · 2026 · 1 citations

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