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September 16, 2025

Discovery of Novel Isophorone Derivatives as Potential Succinate Dehydrogenase Inhibitors: Design, Synthesis, Antifungal Evaluation, and Action Mechanism.

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Authors

HCHongyi ChenZJZunyun JiangWXWang Xiong

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Overview

Evaluation reveals isophorone derivatives reduce fungal growth in six pathogens, suggesting new agricultural applications.

Key Points

  • Compound A2 showed strong antifungal activity with EC50 values ranging from 0.133 to 1.51 μg/mL against six fungi.
  • In vivo tests indicate that Compound A2 serves as a potential candidate to protect crops from fungal infections.
  • Molecular docking and enzyme assays suggest that Compound A2 targets succinate dehydrogenase, sharing mechanisms with other compounds.
  • Results highlight the importance of isophorone derivatives in developing effective antifungal strategies for agriculture.

Cite This Study

Chen et al. (2025) studied this question.

synapsesocial.com/papers/68c93fe601120bef803bb034https://doi.org/10.1021/acs.jafc.5c07416
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  1. 1Discovery of Novel Natural Maltol-Based Derivatives as Potential Succinate Dehydrogenase Inhibitors2025
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