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June 29, 2026Pest Management Science

Design, synthesis and antifungal evaluation of novel indoline‐containing pyrazole‐4‐carboxamide derivatives as potential succinate dehydrogenase inhibitors

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Authors

BLBo LuoYWYanbing WuLYLu Yu

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Overview

Randomized trial evaluates antifungal effectiveness of new compounds against crop pathogens, suggesting potential for improved crop protection.

Key Points

  • The aim is to design and evaluate new succinate dehydrogenase inhibitors for controlling pathogenic fungi affecting crops.
  • Designed and synthesized novel indoline-containing pyrazole-4-carboxamide derivatives.
  • Evaluated antifungal activity in vitro against various fungi such as Rhizoctonia solani and Sclerotinia sclerotiorum.
  • Conducted in vivo tests on crop leaves and fruits to assess the effectiveness of leading compounds.
  • Compound 6j demonstrated superior antifungal efficacy against Rhizoctonia solani with EC50 of 0.04 μg mL-1, outperforming Boscalid (EC50 = 0.40 μg mL-1) and Fluxapyroxad (EC50 = 0.06 μg mL-1).
  • Compound 6i showed potent activity against Sclerotinia sclerotiorum (EC50 = 1.79 μg mL-1) and Valsa mali (EC50 = 3.54 μg mL-1).
  • In vivo tests showed 6j effectively inhibited R. solani growth on rice leaves and 6i suppressed S. sclerotiorum on oilseed rape.

Cite This Study

Luo et al. (2026) studied this question.

synapsesocial.com/papers/6a420b2ff91bb43ea919247bhttps://doi.org/10.1002/ps.71079
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