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August 20, 2026Journal of Agricultural and Food Chemistry

Novel Pyrazole-4-carboxamide Derivatives with a Tetrahydroquinoline Skeleton: Promising SDHIs for the Control of Rhizoctonia solani

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Authors

BLBo LuoYWYanbing WuQZQingsi Zhang

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Overview

In vitro and ex vivo assays demonstrate potent antifungal efficacy of a novel pyrazole-4-carboxamide derivative against Rhizoctonia solani, suggesting its promise as a succinate dehydrogenase...

Key Points

  • To design, synthesize, and assess novel tetrahydroquinoline-based pyrazole-4-carboxamide derivatives as potent succinate dehydrogenase inhibitors (SDHIs) targeting Rhizoctonia solani.
  • Designed and synthesized 30 tetrahydroquinoline-based pyrazole-4-carboxamide derivatives.
  • Screened compounds in vitro for antifungal activity and conducted detached-leaf assays on rice to assess protective and curative efficacy.
  • Evaluated the mechanism of action associated with succinate dehydrogenase (SDH) inhibition.
  • Lead compound 6m demonstrated superior in vitro inhibition against R. solani with an EC50 of 0.03 μg/mL, outperforming commercial controls Boscalid (EC50 = 0.40 μg/mL) and Fluxapyroxad (EC50 = 0.06 μg/mL).
  • Detached-leaf assays on rice confirmed compound 6m markedly suppressed R. solani growth with strong protective and curative effects at 50 μg/mL via SDH-related mechanisms.

Cite This Study

Luo et al. (2026) studied this question.

synapsesocial.com/papers/6a86b5ff8a91293e6a1cd965https://doi.org/10.1021/acs.jafc.6c06276
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Also Consider

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  1. 1Novel Pyrazole-4-Carboxamide Derivatives Containing Oxime Ether Group as Potential SDHIs to Control <i>Rhizoctonia solani</i>2024 · 26 citations
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  3. 3Design, synthesis and antifungal evaluation of novel indoline‐containing pyrazole‐4‐carboxamide derivatives as potential succinate dehydrogenase inhibitors2026
  4. 4Design, Synthesis, and Fungicidal Activity of a New Class of Thiadiazolylpyrimidine Carboxamide Derivatives Against <i>R. solani</i> Kuhn2025
  5. 5Coumarin Hydrazone Derivatives as Potent Succinate Dehydrogenase Inhibitors and Effective Antifungal Agents against <i>Rhizoctonia solani</i>2026