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September 12, 2025Chemistry & Biodiversity

Design, Synthesis, and Fungicidal Activity of a New Class of Thiadiazolylpyrimidine Carboxamide Derivatives Against R. solani Kuhn

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Authors

HRHari Krishnapura Nagaraja raoVDVishwa B. DasVKVinuta Kamat

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Overview

Synthesis of thiadiazolylpyrimidine derivatives reveals antifungal activity against R. solani, suggesting new treatment options.

Key Points

  • Compounds 7a, 7f, and 7k showed moderate antifungal activity, while 7o achieved 100% inhibition of R. solani growth.
  • At 150 ppm concentration, compound 7o recorded excellent inhibition rates, enhancing hopes for novel fungicides in agriculture.
  • The synthesis of bioactive thiadiazolylpyrimidine derivatives aimed to combat the challenges posed by phytopathogenic fungi.
  • This research addresses the urgent need for effective treatments against rice sheath blight impacting global rice production.

Cite This Study

rao et al. (2025) studied this question.

synapsesocial.com/papers/68d44a3031b076d99fa5334chttps://doi.org/10.1002/cbdv.202501520
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