What type of study is this?

This is a Observational study (also classified as: 2D-QSAR, Molecular Docking).

September 10, 2025Chemistry & Biodiversity

Synthesis, Antifungal Activity, Molecular Docking, Aquatic Toxicity Prediction and 2D‐QSAR of Pyrazole Derivatives as Potential Fungicides for Basmati Rice

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Authors

KTK.N. Tripathi RKRakesh Kumar SMSameer Ranjan Misra

Discussion

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Overview

Synthesis of pyrazole derivatives shows notable antifungal activity against sheath blight and bakanae diseases, indicating potential as novel fungicides.

Key Points

Compound 5r demonstrated high antifungal activity with an ED50 of 2.75 µg mL−1 against both pathogens.
2D-QSAR analysis yielded a strong correlation (r2 = 0.973) indicating key molecular descriptors for fungicidal potency.
Molecular docking studies suggest pyrazole derivatives act as succinate dehydrogenase inhibitors, providing a foundation for fungicide design.
Excessive fungicide use leads to resistance and environmental toxicity, necessitating new low-toxicity alternatives like these pyrazole derivatives.

Cite This Study

Tripathi et al. (2025) studied this question.

synapsesocial.com/papers/68c1bb6a54b1d3bfb60ed47e https://doi.org/10.1002/cbdv.202501550

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September 10, 2025Chemistry & Biodiversity

Synthesis, Antifungal Activity, Molecular Docking, Aquatic Toxicity Prediction and 2D‐QSAR of Pyrazole Derivatives as Potential Fungicides for Basmati Rice

View Full Paper

Ask AI

Bookmark

Authors

KTK.N. Tripathi RKRakesh Kumar SMSameer Ranjan Misra

Discussion

Member takes

Overview

Synthesis of pyrazole derivatives shows notable antifungal activity against sheath blight and bakanae diseases, indicating potential as novel fungicides.

Key Points

Compound 5r demonstrated high antifungal activity with an ED50 of 2.75 µg mL−1 against both pathogens.
2D-QSAR analysis yielded a strong correlation (r2 = 0.973) indicating key molecular descriptors for fungicidal potency.
Molecular docking studies suggest pyrazole derivatives act as succinate dehydrogenase inhibitors, providing a foundation for fungicide design.
Excessive fungicide use leads to resistance and environmental toxicity, necessitating new low-toxicity alternatives like these pyrazole derivatives.

Cite This Study

Tripathi et al. (2025) studied this question.

synapsesocial.com/papers/68c1bb6a54b1d3bfb60ed47e https://doi.org/10.1002/cbdv.202501550

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