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October 18, 2025Journal of Agricultural and Food Chemistry

Discovery of Novel Natural Maltol-Based Derivatives as Potential Succinate Dehydrogenase Inhibitors

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Authors

HCHongyi ChenNanjing Agricultural UniversityMYMeng YangHainan UniversityZMZiyun MaiNanjing Agricultural University

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Implication

Novel maltol derivatives exhibit potent antifungal activity against Rhizoctonia solani, suggesting their potential as SDHI fungicides.

Key Points

  • Compound A24 demonstrated significant antifungal effects against multiple phytopathogenic fungi, indicating its broad potential.
  • In vitro testing showed strong efficacy of maltol derivatives, particularly A2 and A24, against Rhizoctonia solani.
  • Molecular docking studies and SDH enzyme activity assays suggest compound A24 as a promising candidate for crop protection.
  • Morphological changes and mitochondrial dysfunction were observed in mycelial structures following treatment with compound A24.

Cite This Study

Chen et al. (2025) studied this question.

synapsesocial.com/papers/68f3eb011cfc5ad53f290719https://doi.org/10.1021/acs.jafc.5c09599
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