What question did this study set out to answer?

This study aims to design and synthesize thiazolyl hydrazide derivatives as new antifungal agents.

Design and synthesis of thiazolyl hydrazide derivatives as potent antifungal agent

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Randomized trial reveals potent antifungal effects of thiazolyl hydrazide derivatives, implying a novel approach to crop protection.

This study aims to design and synthesize thiazolyl hydrazide derivatives as new antifungal agents.
45 thiazolyl hydrazide derivatives synthesized and tested for antifungal activity against seven pathogens.
Structure–activity relationship analyzed; mechanistic studies performed on selected compounds.
Molecular docking and dynamics simulations confirmed binding affinity with succinate dehydrogenase.
Compounds A5 and A33 show significant antifungal activity against Pythium aphanidermatum and Sclerotinia sclerotiorum.
Compound A37 inhibits succinate dehydrogenase with EC50 of 0.49 mg L−1 against Rhizoctonia cerealis and 1.81 mg L−1 against Alternaria alternata.
The derivatives display low toxicity, suggesting promise as eco-friendly antifungal agents.

Wu et al. (2026) studied this question.

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