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September 14, 2025

Design and synthesis of novel imidazo1,2-bpyridazine derivatives bearing arylhydrazine and dithioacetal groups as potential antifungal agents.

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Authors

YLYong LiHebei Agricultural UniversityYZYong ZhangAnhui Agricultural UniversityTWTaotao WuZhejiang Chinese Medical University

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Overview

Synthesis of imidazo[1,2-b]pyridazine derivatives shows broad-spectrum antifungal activity, highlighting potential as new fungicides.

Key Points

  • Compound 5d exhibited superior antifungal effects against Valsa mali and Fusarium solani, outperforming existing fungicides.
  • Synthesis of several imidazo[1,2-b]pyridazine derivatives showed promising antifungal activity against various plant pathogenic fungi.
  • Preliminary mechanistic studies revealed that 5d inhibits spore germination and disrupts mycelial cell wall integrity.
  • Compounds demonstrated favorable safety profiles, indicating potential for agricultural applications with reduced toxicity.

Cite This Study

Li et al. (2025) studied this question.

synapsesocial.com/papers/68c6df6edb42462b79dccc49https://doi.org/10.1002/ps.70219
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