Electrochemical Ferrier Rearrangement of Glycals

The Ferrier rearrangement (FR) is a well-documented reaction that relies on strong acids or oxidants to converts glycals into unsaturated glycosyl derivatives. In this work, we introduce an electrochemical variant of the FR, offering broad substrate compatibility. Various nucleophiles and glycal derivatives afford 2,3-unsaturated glycosyl derivatives in high yields and excellent diastereoselectivities. This sustainable method promises to expand electrochemistry applications in sugar chemistry.