Development study demonstrates in situ fusion-free multiplexed detection of small extracellular vesicle microRNAs, highlighting non-destructive biomarker profiling for cancer diagnostics.
Tumor-derived small extracellular vesicle (sEV) microRNAs (miRNAs) are emerging biomarkers for cancer diagnostics. Conventional sEV miRNA detection methods necessitate the lysis of sEVs, rendering them laborious and time-consuming and potentially leading to damage or loss of miRNAs. Membrane fusion-based
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Zhou et al. (2024) studied this question.
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