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July 29, 2026Analytical Chemistry

Ultrasensitive Detection of Tumor-Derived Extracellular Vesicle microRNAs via Aptamer-Driven Targeted Membrane Fusion and Nonenzymatic Amplification

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Authors

RPRuixiao PengWXWeirong XiaoXXX Xu

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Overview

Randomized trial shows improved detection of tumor-derived miRNAs in cancer patients, suggesting new diagnostic tools.

Key Points

  • The research aims to develop a highly sensitive method for detecting tumor-derived microRNAs in extracellular vesicles.
  • Utilized a targeted fusion approach with aptamer-anchored liposomes to recognize tumor-derived EVs.
  • Implemented nonenzymatic amplification techniques to enhance detection sensitivity.
  • Employed flow cytometry for quantifying EV-associated proteins and microRNAs.
  • Achieved a detection limit of 4 ng/mL for EV-associated proteins and 0.2 fM for EV miR-21.
  • Successfully discriminated between cancer patients and healthy controls.
  • Demonstrated promise for applications in early cancer diagnosis and monitoring.

Cite This Study

Peng et al. (2026) studied this question.

synapsesocial.com/papers/6a69a2e2c8da07d9defa6f51https://doi.org/10.1021/acs.analchem.6c02962
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Anionic Liposomes as Optimal Membrane Fusion Carriers Enabling in Situ Multiplexed Detection of Extracellular Vesicle MicroRNAs2025
  2. 2Multistage Cascade-Hierarchical Nucleic Acid Amplification for Label-Free Ultrasensitive Electrochemical Sensing of Tumor-Associated Extracellular Vesicles2026 · 2 citations
  3. 3Precise Mutation Detection in Low-Abundance Tumor-Derived Extracellular Vesicles via Microfluidic Immunomagnetic Reversible Affinity Capture2026
  4. 4Ultrasensitive and Wash-Free Detection of Tumor Extracellular Vesicles by Aptamer-Proximity-Ligation-Activated Rolling Circle Amplification Coupled to Single Particle ICP-MS2024 · 31 citations
  5. 5Harnessing microRNA-enriched extracellular vesicles for liquid biopsy2024 · 17 citations