September 19, 2024

LiverMap pipeline for 3D imaging of human liver reveals volumetric spatial dysregulation of cirrhotic vasculobiliary architecture

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Authors

WFWesley B. Fabyan CFChelsea L. Fortin HKHeidi L. KenersonUniversity of Washington

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Implication

Imaging analysis reveals vasculobiliary disruption and a pro-portalization phenotype in cirrhotic human liver tissue, highlighting severe volumetric architectural decay.

Key Points

Sinusoid zonation dysregulation and biliary network fragmentation dominate human cirrhotic liver samples, driving a pronounced tissue-wide pro-portalization phenotype.
Assessment using immunostaining, tissue clearing, and three-dimensional microscopy revealed marked reductions in glutamine synthetase-expressing pericentral hepatocytes.
Volumetric pathological analyses of vasculobiliary architecture may uncover novel mechanisms of cirrhotic pathobiology and inspire future targeted clinical therapies.

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Fabyan et al. (2024) studied this question.

synapsesocial.com/papers/68e57fbcb6db64358751d89c https://doi.org/10.1101/2024.09.14.613049

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Implication

Imaging analysis reveals vasculobiliary disruption and a pro-portalization phenotype in cirrhotic human liver tissue, highlighting severe volumetric architectural decay.

LiverMap pipeline for 3D imaging of human liver reveals volumetric spatial dysregulation of cirrhotic vasculobiliary architecture

Discussion

Member takes

Implication

Key Points

Cite This Study

LiverMap pipeline for 3D imaging of human liver reveals volumetric spatial dysregulation of cirrhotic vasculobiliary architecture

Discussion

Member takes

Implication

Key Points

Cite This Study

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