Development of a Stereospecific Strategy for the Total Synthesis of Diplodialide C and Formal Synthesis of (–)-Curvularin

A concise and efficient stereospecific approach for the total synthesis of diplodialide C (R,R and S,S isomers) has been demonstrated using chiral homoglycidol and propylene oxide as a source of starting material. Further oxidized ketolide product derived from diplodialide C (S,S isomer) was applied to the formal synthesis of (–)-curvularin following reported known literature.