A study of cognitive functions in elderly men of the Arctic region of the Russian Federation with arterial hypertension using the auditory event-related potentials p300

The aim is to study the effect of with arterial hypertension on cognitive functions by evaluating the auditory event-related potentials (ERP) p300 in men aged 60-74 years of the Arctic region of the Russian Federation receiving antihypertensive therapy with controlled arterial hypertension and in men who do not take antihypertensive drugs or take them both regularly and irregularly, but do not control blood pressure. Methods. The study involved men with arterial hypertension (AH) (n=64) and without hypertension (n=19) in Arkhangelsk. Registration of the p300 and N2 components was performed on the Neuron-Spektr-4/VPM electroencephalograph (Neurosoft, Russia), using the oddball paradigm. Blood pressure (BP) was measured with an automatic tonometer AD Medical UA-668 (Japan). Results. In men without arterial hypertension and in men with controlled arterial hypertension, where the median values of systolic blood pressure (SBP) and diastolic blood pressure (DBP) were within normal values, there were no differences in the latent time (LT) of N2 and p300 and the magnitude of the p300 amplitude between these groups. In men who do not take antihypertensive drugs or receive antihypertensive therapy both regularly and irregularly, but do not control blood pressure and have SBP and DBP above normal values, there was an elongation of LT N2 in the parietal (P3), central (C3), middle temporal (T3) sections on the left, in the frontal section on the right (F4), an elongation of LV P300 in the middle-temporal region on the right (T4) and frontal regions on the right (F4) and a decrease in the median values of the amplitude of p300 in the anterior-temporal (F8,F7) parts of the brain, which indicates a deficit of attention, an increase in the time of primary recognition and differentiation of the signal, reducing the speed of information processing and decision-making. Conclusion.Inoldermen, SBPabove140mmHgandDBPabove90mmHg are associatedwithcognitiveimpairment as determinedby the auditory event-related potentials P300.