Key result
A nondipping blood pressure pattern was not associated with lower cognitive function, as measured by MMSE scores and event-related brain potentials, in elderly patients with recently diagnosed hypertension.
Why the study?
Does a nondipping blood pressure pattern affect cognitive function in elderly patients with recently diagnosed hypertension?
Cross-Sectional (n=30)
No
Does a nondipping blood pressure pattern affect cognitive function in elderly patients with recently diagnosed hypertension?
Answers are grounded in this paper and cite their sources.
In elderly patients with recently diagnosed, untreated hypertension, a nondipping blood pressure pattern is not associated with lower cognitive function compared to a dipping pattern.
Several studies have shown a relationship between blood pressure (BP) and cognitive function. Yet very few studies have addressed circadian BP patterns in this context, perhaps due to poor availability of suitable methods to detect slight changes in the cognitive state. Today, brain event-related potentials (ERPs) allow us to detect subclinical changes in cognitive function. We enrolled 30 elderly patients with recently diagnosed hypertension (<2 years) that had never been treated: 18 dippers and 12 nondippers. Patients underwent 24-h ambulatory blood pressure monitoring (ABPM). Careful assessment of their cognitive state was carried out using the mini mental state examination (MMSE), and the recording of P300 and N2 ERPs. No significant differences between the two groups were found. MMSE scores in dippers and nondippers were similar (29.5+/-0.71 vs. 29.3+/-1.07, respectively; p =0.611), as were P300 latency values (377.78+/-33.28 vs. 364.67+/-35.12 in the central (Cz) position, p =0.310; 379.22+/-32.94 vs. 365.25+/-35.07 in the occipital (Pz) position, p =0.277) and N2 wave latency values (253.83+/-24.9 vs. 249.17+/-24.47 in the Cz position, p =0.617; 251.56+/-25.86 vs. 246.58+/-25.46 in the Pz position, p =0.608). These data show no association between the nondipping pattern and lower cognitive function in elderly subjects with recent hypertension.
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Cicconetti et al. (2004) conducted a cross-sectional in Recently diagnosed hypertension (n=30). Nondipping blood pressure pattern vs. Dipping blood pressure pattern was evaluated on Mini Mental State Examination (MMSE) score (p=0.611). A nondipping blood pressure pattern was not associated with lower cognitive function, as measured by MMSE scores and event-related brain potentials, in elderly patients with recently diagnosed hypertension.
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