Key result
A non-dipping blood pressure pattern was not associated with lower cognitive function compared to a dipping pattern in newly diagnosed, never-treated older hypertensives.
Why the study?
Does a non-dipping blood pressure pattern reduce cognitive function in newly diagnosed older hypertensives?
Cross-Sectional (n=40)
Does a non-dipping blood pressure pattern reduce cognitive function in newly diagnosed older hypertensives?
In newly diagnosed, untreated older hypertensives, a non-dipping blood pressure pattern is not associated with lower cognitive function compared to a dipping pattern.
Answers are grounded in this paper and cite their sources.
Non-dipping pattern shows no cognitive association in new older hypertensives; leaves open need for longitudinal confirmation before clinical use.
Hypertensive subjects can be subdivided in two groups, dippers and non-dippers, according to the presence or the lack of a nocturnal fall of blood pressure (BP) of over 10%. Several studies have investigated cardiovascular and cerebrovascular organ damage in the two groups with discordant results, but fewer of them analysed the relationship between circadian BP pattern and cognitive function, and none in the early phases of hypertension. To this purpose, we selected 40 older hypertensives, 23 dippers and 17 non-dippers, with newly diagnosed hypertension, never treated, who underwent to 24-h ambulatory BP monitoring (ABPM), Mini-Mental State Examination (MMSE) and recording of event-related potentials (ERPs). No significant differences between dippers and non-dippers were found in the MMSE scores and P300 latency values, as we expected, and not even in N2 wave latency values, showing that the non-dipping pattern is not associated with lower cognitive function in the early phases of hypertension.
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Cicconetti et al. (2003) conducted a cross-sectional in Newly diagnosed hypertension (n=40). Non-dipping blood pressure pattern vs. Dipping blood pressure pattern was evaluated on Cognitive function (MMSE scores, P300 and N2 wave latency values). A non-dipping blood pressure pattern was not associated with lower cognitive function compared to a dipping pattern in newly diagnosed, never-treated older hypertensives.
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