Key result
Taking one antihypertensive drug before bedtime significantly reduced the prevalence of a non-dipper blood pressure pattern compared to taking all drugs upon awakening (49.4% vs 81.5%, P<0.001).
Why the study?
Does bedtime administration of antihypertensive therapy reduce the prevalence of non-dipper blood pressure pattern in elderly patients with essential hypertension compared to morning administration?
Population
682 elderly patients (age ≥65 years) with grade 1–2 essential hypertension, mean age 70.9±4.7 years, 295 men.
Comparison
Antihypertensive therapy with at least one drug… vs Antihypertensive therapy with all drugs…
Design
Cross-sectional
Follow-up
48 hours
Authors
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Hypothesis-generating for bedtime dosing in elderly hypertension; prospective trials needed before clinical adoption.
Observational (n=682)
Does bedtime administration of antihypertensive therapy reduce the prevalence of non-dipper blood pressure pattern in elderly patients with essential hypertension compared to morning administration?
Absolute Event Rate: 49.4% vs 81.5%
p-value: p=<0.001
Administering at least one antihypertensive drug at bedtime significantly reduces the prevalence of the high-risk non-dipper blood pressure pattern in elderly patients compared to morning-only administration.
Carlos Calvo (2004) conducted an observational in Grade 1-2 essential hypertension (n=682). Antihypertensive treatment before bedtime vs. All antihypertensive drugs upon awakening was evaluated on Prevalence of non-dipper blood pressure pattern (p=<0.001). Taking one antihypertensive drug before bedtime significantly reduced the prevalence of a non-dipper blood pressure pattern compared to taking all drugs upon awakening (49.4% vs 81.5%, P<0.001).
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