Key result
Older age (≥60 years) was associated with a higher prevalence of non-dipping blood pressure compared to younger patients (63.1% vs 41.1%, p<0.001), an effect attenuated by bedtime medication dosing.
Why the study?
Does bedtime ingestion of hypertension medications improve nighttime blood pressure regulation compared to morning ingestion in hypertensive patients across different ages?
Population
6,147 hypertensive patients, mean age 54.0 ± 13.7 years, including 2,137 patients ≥60 years of age. 1,809…
Comparison
Ingestion of the full daily dose of ≥1… vs Ingestion of all prescribed BP-lowering…
Design
Cross-sectional
Authors
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Age may alter nocturnal BP dipping; leaves open whether treatment timing modifies this in elderly.
Cross-Sectional (n=6,147)
Does bedtime ingestion of hypertension medications improve nighttime blood pressure regulation compared to morning ingestion in hypertensive patients across different ages?
Absolute Event Rate: 63.1% vs 41.1%
p-value: p=<.001
Older age is associated with a blunted nighttime blood pressure decline, but ingesting at least one hypertension medication at bedtime significantly improves nighttime blood pressure regulation across all ages compared to morning dosing.
Hermida et al. (2012) conducted a cross-sectional in Hypertension (n=6,147). Older age (≥60 years) vs. Younger age (<60 years) was evaluated on Prevalence of non-dipping blood pressure pattern (p=<.001). Older age (≥60 years) was associated with a higher prevalence of non-dipping blood pressure compared to younger patients (63.1% vs 41.1%, p<0.001), an effect attenuated by bedtime medication dosing.
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