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August 9, 2005HypertensionOpen Access

Effects of Time of Day of Treatment on Ambulatory Blood Pressure Pattern of Patients With Resistant Hypertension

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Why the study?

Does taking ≥1 antihypertensive drug at bedtime improve ambulatory blood pressure patterns in patients with resistant hypertension?

Population

700 patients with resistant hypertension based on clinic measurements (578 with true resistant hypertension)

Comparison

Taking ≥1 antihypertensive drug at bedtime vs Receiving all antihypertensive medication on…

Design

Cohort

Follow-up

48-hour

Authors

RHRamón C. HermidaPreventive CardiologyDADiana E. AyalaPreventive CardiologyCCCarlos CalvoApple (Israel)

Discussion

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Member takes

Overview

May support bedtime dosing in resistant hypertension; hypothesis-generating, requires randomized confirmation before practice change.

Structured PICO

Does taking ≥1 antihypertensive drug at bedtime improve ambulatory blood pressure patterns in patients with resistant hypertension?

P
Population
700 patients with resistant hypertension based on clinic measurements (578 with true resistant hypertension)
I
Intervention
Taking ≥1 antihypertensive drug at bedtime
C
Comparator
Receiving all antihypertensive medication on awakening
O
Outcome
Ambulatory blood pressure pattern (24-hour mean systolic and diastolic blood pressure, nighttime blood pressure, diurnal/nocturnal blood pressure ratio, and prevalence of non-dipping) measured by 48-hour ambulatory monitoringsurrogate

Administering at least one antihypertensive medication at bedtime significantly improves 24-hour ambulatory blood pressure control and reduces the non-dipper pattern in patients with resistant hypertension.

Cite This Study

Hermida et al. (2005) studied this question.

synapsesocial.com/papers/6a83dbc754d5d3123e3c2e2ehttps://doi.org/10.1161/01.hyp.0000172757.96281.bf

Topics

Hypertension management
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Twenty-four hour ambulatory blood pressure monitoring pattern of resistant hypertension2003 · 136 citations
  2. 2Ambulatory blood pressure. An independent predictor of prognosis in essential hypertension.1994 · 1,682 citations
  3. 3Administration-Time-Dependent Effects of Doxazosin GITS on Ambulatory Blood Pressure of Hypertensive Subjects2004 · 84 citations
  4. 4Prognostic Value of Ambulatory Blood Pressure Monitoring in Refractory Hypertension1998 · 420 citations
  5. 5Ambulatory Blood Pressure and 10-Year Risk of Cardiovascular and Noncardiovascular Mortality2005 · 417 citations