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September 17, 2024American Journal of Dermatopathology

Histopathologic Analysis of Chronic Cutaneous Graft-Versus-Host Disease

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Authors

SASavannah M. AlvaradoOCOlivia G. CohenKLKatherine Lattanzio

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Overview

Histopathologic analysis reveals inflammatory disease patterns in cutaneous graft-versus-host disease, highlighting implications for disease endotyping and personalized therapy.

Key Points

  • Active tissue injury manifests alongside inflammatory patterns resembling common dermatoses in chronic graft-versus-host disease biopsies, with minimal classic features present.
  • Apoptosis occurred in 94.0% of epidermal specimens along the epidermal basal layer, with vacuolar change concurrently identified in 92.5% of biopsies.
  • Histopathologic analysis of eighty-three tissue specimens categorized cutaneous lesions after hematopoietic cell transplantation, detailing distinct disease patterns.
  • Highlights the necessity of complete histologic reporting to advance clinical endotyping and personalized therapy for chronic graft-versus-host disease manifestations.

Cite This Study

Alvarado et al. (2024) studied this question.

synapsesocial.com/papers/68e5832cb6db643587520705https://doi.org/10.1097/dad.0000000000002841
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Impact of Chronic Graft-versus-Host Disease on Late Relapse and Survival on 7,489 Patients after Myeloablative Allogeneic Hematopoietic Cell Transplantation for Leukemia2014 · 128 citations
  2. 2Long-Term Survival and Late Deaths After Allogeneic Hematopoietic Cell Transplantation2011 · 637 citations
  3. 3Nonrelapse mortality among patients diagnosed with chronic GVHD: an updated analysis from the Chronic GVHD Consortium2021 · 146 citations
  4. 4Classification systems for chronic graft-versus-host disease2016 · 315 citations
  5. 5Methods to Assess Disease Activity and Severity in Cutaneous Chronic Graft-versus-Host Disease: A Critical Literature Review2021 · 12 citations