September 16, 2024

Supplementary Figure S13 from Single-cell RNA analysis reveals cell-intrinsic functions of CAR-T cells correlating with response in a phase II study of lymphoma patients

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CAR-T cells exhibit distinct functional activation patterns following in vitro CD19 antigen stimulation, correlating with clinical outcomes in lymphoma patients.
Single-cell RNA analysis characterizes intrinsic transcriptional programs of CAR-T cells after target antigen engagement across phase II trial patient samples.
Assessment of cell-intrinsic functions provides mechanistic insight into therapeutic variability, supporting optimized cellular engineering for lymphoma therapy.

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Implication

Phase II trial analysis demonstrates CAR-T cell responses to in vitro CD19 antigen stimulation in lymphoma patients, highlighting cell-intrinsic determinants of therapeutic efficacy.

Abstract

Supplementary Figure S13. CAR-T response to in vitro CD19 antigen stimulation

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Sarén et al. (2024) studied this question.

synapsesocial.com/papers/68e586c1b6db643587523837 https://doi.org/10.1158/1078-0432.27034081

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Implication

Phase II trial analysis demonstrates CAR-T cell responses to in vitro CD19 antigen stimulation in lymphoma patients, highlighting cell-intrinsic determinants of therapeutic efficacy.

Abstract

Supplementary Figure S13. CAR-T response to in vitro CD19 antigen stimulation

Supplementary Figure S13 from Single-cell RNA analysis reveals cell-intrinsic functions of CAR-T cells correlating with response in a phase II study of lymphoma patients

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Implication

Abstract

Discussion

Cite This Study

Supplementary Figure S13 from Single-cell RNA analysis reveals cell-intrinsic functions of CAR-T cells correlating with response in a phase II study of lymphoma patients

Key Points

No abstract yet

Implication

Abstract

Discussion

Cite This Study

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