September 16, 2024

Supplementary Figure S9 from Single-cell RNA analysis reveals cell-intrinsic functions of CAR-T cells correlating with response in a phase II study of lymphoma patients

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Specific gene expression profiles in CD4+ CAR-T cells correlate with treatment response, demonstrating that cell-intrinsic functions shape therapeutic outcomes in lymphoma.
Single-cell RNA analysis characterizes transcriptional variations across CD4+ CAR-T cells, linking distinct molecular signatures directly to clinical response in lymphoma.
Highlights the importance of CD4+ CAR-T cell-intrinsic functions in phase II clinical trials, which may enable refined cellular profiling strategies for lymphoma treatment.

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Implication

Phase II study reveals CD4+ CAR-T cell gene expression patterns correlating with clinical response in lymphoma patients, highlighting cell-intrinsic determinants of therapy efficacy.

Abstract

Supplementary Figure S9. Gene expression of CD4+ CAR-Ts and relation to response

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Sarén et al. (2024) studied this question.

synapsesocial.com/papers/68e586c1b6db643587523946 https://doi.org/10.1158/1078-0432.27034057.v1

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Implication

Phase II study reveals CD4+ CAR-T cell gene expression patterns correlating with clinical response in lymphoma patients, highlighting cell-intrinsic determinants of therapy efficacy.

Abstract

Supplementary Figure S9. Gene expression of CD4+ CAR-Ts and relation to response

Supplementary Figure S9 from Single-cell RNA analysis reveals cell-intrinsic functions of CAR-T cells correlating with response in a phase II study of lymphoma patients

Key Points

No abstract yet

Implication

Abstract

Discussion

Cite This Study

Supplementary Figure S9 from Single-cell RNA analysis reveals cell-intrinsic functions of CAR-T cells correlating with response in a phase II study of lymphoma patients

Key Points

No abstract yet

Implication

Abstract

Discussion

Cite This Study

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