Effect of Ranitidine on Hypoglycaemic Activity of Glipizide in Rabbits

Objective: To study the effect of Ranitidine (H2 receptor antagonist) in combination with Glipizide on the blood sugar level in rabbits. Methods: Six albino rabbits were taken for the study. Glipizide was administrated to each rabbit as a single drug therapy on day 1, while was co-administrated with Ranitidine to each rabbit as a combinational drug therapy on day 7. Ranitidine was administrated to each rabbit from day 2 to day 6 as a single drug therapy. Blood sugar levels were estimated on day 1 and on day 7 at 0, 1, 2, 4, and 6 h. Results: The mean blood sugar level readings at 0, 1, 2, 4 and 6 h on day 1 were 90.9, 78.4, 67.2, 60.2 and 67.5 mg% and on day 7 were 90.3, 77.01, 63.3, 55.7 and 64 mg% respectively. When mean blood sugar level on day 1 and day 7 were considered, there was a significant reduction in blood sugar level at 2, 4 and 6 h but there was no significant fall in blood sugar level at 0 and 1 hour after co-administration of Glipizide and Ranitidine. Conclusion: Ranitidine, when co-administered with glipizide, significantly increases the hypoglycaemic action of glipizide.