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September 12, 2024CellsOpen Access

Threonine Phosphorylation and the Yin and Yang of STAT1: Phosphorylation-Dependent Spectrum of STAT1 Functionality in Inflammatory Contexts

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Authors

MEMaha M. ElbrashyHMHozaifa MetwallySSShuhei Sakakibara

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Cite This Study

Elbrashy et al. (2024) studied this question.

synapsesocial.com/papers/68e58b97b6db643587526ff9https://doi.org/10.3390/cells13181531
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Threonine phosphorylation of STAT1 restricts interferon signaling and promotes innate inflammatory responses2024 · 24 citations
  2. 2Targeted Inhibition of Interferon-γ-dependent Intercellular Adhesion Molecule-1 (ICAM-1) Expression Using Dominant-Negative Stat11997 · 100 citations
  3. 3IFNγ shapes macrophage inflammatory responses by STAT1 isoform-specific epigenetic and transcriptional mechanisms2026 · 3 citations
  4. 4Nuclear export block of tyrosine-phosphorylated STAT1 facilitates rapid responsiveness to interferon-γ stimuli at the expense of signal strength2026
  5. 5TCR signaling induces STAT3 phosphorylation to promote TH17 cell differentiation2024 · 61 citations