A one-pot synthesis method to produce alkyl nitriles using the corresponding aliphatic carboxylic acid has been developed. The process involves treating the aliphatic acid with thionyl chloride to obtain the corresponding aliphatic acid chloride, which is then further treated with anhydrous ammonia gas to yield the respective aliphatic acid amide. The intermediate corresponding amide is dehydrated with thionyl chloride to obtain alkyl nitrile with a quantitative yield.
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Patil et al. (2024) studied this question.
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