One-pot protocol for the synthesis of N -substituted amides from nitriles and alcohols using thiamine hydrochloride (VB ₁ ) under solvent-free conditions

A new and convenient protocol for the synthesis of N-substituted amide analogs has occurred from nitriles and secondary alcohols using thiamin hydrochloride (VB1) as an organocatalyst. This protocol is an alternate synthetic route to the formation of amides by the Ritter reaction, which is one of the most useful methods for the preparation of N-substituted amides from nitriles to alcohols. In this protocol, firstly, thiamin hydrochloride (VB1) activates the alcohol attacked by nitrile to form N-substituted amide derivatives. This protocol can also be used for the preparation of benzhydryl ether. The novel route has been develop for the synthesis of N-substituted amide from alcohol using thiamin hydrochloride as a green organocatalyst.