Methodological synthesis reveals deuterated reagents in multicomponent reactions generate deuterium-labeled products, highlighting utility for bio-isosteric drug discovery.
The utility of bio-isosteres is broad in drug discovery and methodology herein enables the preparation of deuterium-labeled products is the most fundamental of known bio-isosteric replacements. As such we report the use of both [D
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Schofield et al. (2024) studied this question.
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