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September 4, 2024IP Indian Journal of Clinical and Experimental DermatologyOpen Access

A comparative study on therapeutic efficacy between methotrexate iontophoresis and topical methotrexate 1% gel in palmoplantar psoriasis

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Authors

JVJayakalyani VijayananthSVSridhar VenuNINithya Iyappan

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Overview

Randomized trial demonstrates superior lesion clearance with methotrexate iontophoresis over topical gel in palmoplantar psoriasis, indicating enhanced transdermal delivery improves outcomes.

Key Points

  • Methotrexate iontophoresis achieved significantly higher lesion clearance than topical gel in palmoplantar psoriasis, markedly reducing erythema, scaling, and painful fissuring.
  • Overall improvement reached 95.3% with iontophoresis compared to 82.4% for topical methotrexate gel, confirming statistically superior clinical efficacy between the two cohorts.
  • Comparative assessment of 60 patients demonstrates that electrical delivery enhances methotrexate absorption, offering an effective localized alternative to systemic therapy.

Cite This Study

Vijayananth et al. (2024) studied this question.

synapsesocial.com/papers/68e59691b6db64358753166dhttps://doi.org/10.18231/j.ijced.2024.049
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Palmoplantar Lesions in Psoriasis: A Study of 3065 Patients2002 · 105 citations
  2. 2Topical 0.25% Methotrexate Gel in a Hydrogel Base for Palmoplantar Psoriasis2004 · 35 citations
  3. 3The Development of Practice Guidelines for the Treatment of Severe Plaque Form Psoriasis1998 · 44 citations